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登革热病毒抗体推荐

放大字体  缩小字体 发布日期:2014-06-04  作者:欣博盛  浏览次数:15
公司介绍:欣博盛生物科技有限公司

 


The Dengue virus (DEN) is of the genus Flavivirus and possesses a positive-strand RNA genome of approximately 10.6 kb that contains a single open-reading frame encoding for a polyprotein, which can be further cleaved by cellular and viral proteases into three structural proteins (capsid protein C, membrane protein M, envelope protein E), and seven non-structural proteins (NS 1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). There are four serotypes (DEN 1-4), though there is certainly genotypic variability in individual viral genomes within each serotype. This variability is thought to have minimal clinical significance , as human infection from any of the four serotypes results in long-term immunity to that serotype . However, cross-immunity between serotypes is of much shorter duration , meaning that many people are victims of sequential infection by different serotypes. This is clinically very important, as sequential infection appears to be a risk factor for more serious disease manifestations.


Dengue Virus Protein Schematic Diagram (Non-Structural Proteins (Orange)


Dengue virus 1, 2, 3 & 4 antibody [D1-11 (3)] (GTX29202)                                NS1 (Dengue virus ) antibody [GT1 061] (GTX630SS7)
Dengue virus antibody detects Dengue virus 1 protein at                                 NS1 antibody detects NS1 (Dengue virus) protein at 
cytoplasm by immunofluorescent analysis                                                          cytoplasm by immunofluorescent analysis


Envelope protein (Dengue virus) antibody [GT214] (GTX629116)                   WB analysis for all blots
Envelope protein antibody detects Envelope protein (Dengue                         A: BHK-21; B: DEN2-infecled BHK-21; C: JEV-infecled BHK
virus) protein at cytoplasm by immunofluorescent analysis                             -21 Blols probed wilh Rb pAb 10 (Ieft 10 righl): NS1 (GTX124
                                                                                                                                      280);
 NS2B (GTX124246); NS3 (GTX124252); NS4B (GTX124
                                                                                                                                      250); NS5 (GTX124253)
 
 Cat.NO
 Product
 Reactivity
 Host&Clonality
 Application
GTX29202
Dengue Virus 1, 2, 3 & 4 antibody [D1-11(3)]
DEN
Ms mAb IgG2a
Dot blot, ELlSA, ICC/IF, WB
GTX41428
 Dengue Virus Type 2 antibody [NYRDeng2]
DEN2
Ms mAb IgG1
ELISA. WB
GTX43295
 Dengue Types 1,2,3,4 antibody [BDI419]
DEN
Ms mAb IgG2a
Dot blot, ELlSA, ICC川F
GTX41437
 Dengue Virus antibody [5161]
DEN
Ms mAb IgG2a
ELISA
GTX41430 
 Dengue Virus Type 2 antibody [3H5.1]
DEN2
Ms mAb IgG1
ICC/IF
GTX43296
 Dengue Type 2, envelope antibody [B932M]
DEN2
Ms mAb IgG1
ICC/IF
GTX124247
Capsid Protein (Dengue Virus) antibody
Capsid (DEN)
Rb pAb
WB
GTX103343
Capsid Protein (Dengue Virus) antibody
Capsid (DEN)
Rb pAb
ICC/IF. WB
GTX128092
PrM (Dengue Virus) antibody
PrM (DEN)
Rb pAb
WB
GTX128093
PrM (Dengue Virus) antibody
PrM (DEN)
Rb pAb
WB
GTX127277
Envelope protein (Dengue Virus) antibody
Envelope (DEN)
Rb pAb
ICC/IF. WB
GTX629116
Envelope protein (Dengue Virus) antibody [GT214]
Envelope (DEN)
Ms mAb IgG2a
ICC/IF. WB
GTX629117
Envelope protein (Dengue Virus) antibody [GT643]
Envelope (DEN)
Ms mAb IgG2b
ICC/IF. WB
GTX630557
NS1 (Dengue virus) antibody [GT1061]
NS1 (DEN)
Ms mAb IgG1(NEW Producr)
ICC/IF. WB
GTX630556
NS1 (Dengue virus) antibody [GT4212]
NS1 (DEN)
Ms mAb IgG2a(NEW Producr)
ICC/IF. WB
GTX103346
NS1 (Dengue Virus 2) antibody
NS1 (DEN2)
Rb pAb
ICC/IF. WB
GTX124280
NS1 (Dengue Virus) antibody
NS1 (DEN)
Rb pAb
ICC/IF. WB
GTX124246
NS2B (Dengue Virus) antibody
NS2B (DEN)
Rb pAb
ICC/IF. WB
GTX124252
NS3 (Dengue Virus) antibody
NS3 (DEN)
Rb pAb
ICC/IF. WB
GTX629477
NS3 (Dengue Virus) antibody [GT2811]
NS3 (DEN)
Ms mAb IgG1
ICC/IF. WB
GTX124249
NS4A (Dengue Virus) antibody
NS4A (DEN)
Rb pAb
WB
GTX103349
NS4B (Dengue Virus) antibody
NS4B (DEN)
Rb pAb
ICC/IF. WB
GTX124250
NS4B (Dengue Virus) antibody
NS4B (DEN)
Rb pAb
ICC/IF. WB
GTX103350
NS5 (Dengue Virus) antibody
NS5 (DEN)
Rb pAb
ICC/IF. WB
GTX124253
NS5 (Dengue Virus) antibody
NS5 (DEN)
Rb pAb
ICC/IF. WB
GTX629446
NS5 (Dengue Virus 2) antibody [GT353]
NS5 (DEN)
Ms mAb IgG2b
ICC/IF. WB
GTX629447
NS5 (Dengue Virus 2) antibody [GT361]
NS5 (DEN)
Ms mAb IgG1
ICC/IF. WB
Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called
serotypes. All four dengue serotypes circulate together in tropical and subtropical regions around the world.


The Viral genome is translated as a single, long polypeptide and then cut into ten proteins.


Three are structural proteins: the capsid (C), envelope (E), and membrane (M) proteins. Seven are nonstructural proteins: NS1, NS2A, 
NS2B, NS3, NS4A, NS4B, and NS5. These nonstructural proteins play roles in viral replication and assembly.

 Proteins  Functions  GeneTex Antibodies
 Structure  
 Proteins
 Capsid  Encapsidation of the RNA genome. May regulate host 
 cell apoptosis through stabilizing P53
 GTX124247, GTX103343
 Envelope  Allowing virus to enter host cells. Essential target of  
 antiviral vaccine ★. 
 GTX43296
 Membrane  Compose viral membrane structure  GTX127277, GTX629116, 
 GTX629117,
 Non-Structure  
 Proteins
 NS1  Essential for virus replication, as a target of humural 
 immunity.
 GTX630556,
 GTX630557, GTX103346,    
 GTX124280,
 NS2A, 2B  Viral RNA synthesis, virion assembly/maturation, and 
 antagonizes the host immune response
 GTX124246 (2B)
 NS3  Protease/ nucleotide triphosphatases and helicase  
 activity used for viral RNA synthesis. 
 GTX124252, GTX629477,
 NS4A, 4B  Blocking IFNa/b signaling and involved in STAT pathway  
 in host cells.
 GTX124249 (4A), GTX103349 (4B), 
 GTX124250 (4B)
 NS5  Viral RNA polymerase and methyltransferase.   GTX103350, GTX124253,  
 GTX629446, GTX629447
 GeneTex Antibodies against whole 
 virons
 GTX29202, GTX41428, GTX43295, GTX41437, GTX41430

 

 
关键词: dengue virus 登革热
 
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